Multiple aggregation factors in cartilage proteoglycan (Short Communication)
نویسندگان
چکیده
منابع مشابه
Hyaluronic acid in cartilage and proteoglycan aggregation.
1. Dissociation of purified proteoglycan aggregates was shown to release an interacting component of buoyant density higher than that of the glycoprotein-link fraction of Hascall & Sajdera (1969). 2. This component, which produced an increase in hydrodynamic size of proteoglycans on gel chromatography, was isolated by ECTEOLA-cellulose ion-exchange chromatography and identified as hyaluronic ac...
متن کاملMolecular conformations in proteoglycan aggregation.
that murein will eventually be discovered to require an apoprotein as the initiator, as is turning out to be the case with a number of, what were for long thought to be, ‘pure’ polysaccharides. Examples are the proteoglycans of connective tissue, and storage polysaccharides such as glycogen. No less exciting have been the developments in understanding the stereochemistry of the proteoglycans, t...
متن کاملArticular cartilage proteoglycan biosynthesis and sulfation
Glucosamine (GlcN) and glucosamine sulfate (GS) have been used to treat the patients with osteoarthritis (OA) as a disease-modifying agent. Previous in vitro studies have focused on the effects of GlcN or GS on cartilage metabolism, whereas in vivo studies have investigated their potential for the treatment of OA. Although these results have raised promises of the disease-modifying effects of G...
متن کاملNon-electrostatic factors govern the hydrodynamic properties of articular cartilage proteoglycan.
The hydrodynamic frictional resistance to water flow exerted by articular cartilage proteoglycan is shown to be similar to that of proteoglycan isolated from Swarm rat chondrosarcoma, and independent of the state of aggregation of the proteoglycan. Frictional resistance is dependent, however, on the chain segments of the constituent chondroitin-sulphate and keratan-sulphate chains of the proteo...
متن کاملDomain structure and sequence similarities in cartilage proteoglycan.
the length of the polypeptide. In the second (CS2), the glycosaminoglycans occur as clusters separated by gaps. The current view of the aggregating cartilage proteoglycan is thus of a multidomain structure. Because the interaction with hyaluronate is fundamental to the role these molecules play in cartilage, a good deal of attention has been focused on the molecular structure of this domain. Th...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1973
ISSN: 0264-6021
DOI: 10.1042/bj1330383